Gather all ingredients and preheat the oven to 400°F (200°C).

Season the pork tenderloin generously with salt and pepper.

In a skillet, heat the olive oil over medium-high heat and sear the pork on all sides until browned, about 3-4 minutes per side.

In a saucepan, combine cranberries, orange juice, honey, and soy sauce. Bring to a gentle boil, stirring occasionally, for about 10 minutes until cranberries burst and sauce thickens.

Pour the cranberry glaze over the seared pork tenderloin and transfer the skillet to the preheated oven.

Bake for 20-25 minutes, or until the internal temperature reaches 145°F (63°C).

Let the pork rest for a few minutes after removing it from the oven.

Slice the pork tenderloin into medallions and drizzle with remaining glaze before serving.